Action Members are any researcher who participates actively in PROTEOSTASIS. All Members belong to one or more Working Group. Members can include researchers from COST Countries, Near Neighbour and International Partner Countries.

Ioannis Nezis

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School of Life Sciences, University of Warwick
http://www2.warwick.ac.uk
UK
WG2
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Biochemical methods, Drosophila genetics, immunofluorescence, confocal microscopy, live imaging, transmission and scanning electron microscopy, cryo-immuno-gold labelling, correlative light-electron microscopy, negative staining, structural bioinformatics, proteomics.
Ioannis Trougakos

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National & Kapodistrian University of Athens. Faculty of Biology 
No website
Greece
WG2
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Speciality: The
Isabelle Jupin

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Virologie Moleculaire. Institut Jacques Monod. UMR 7592 CNRS - Universite Paris 7
http://www.ijm.fr
France
WG1
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Our main research interest concerns the molecular mechanisms of viral RNA replication. Lately, we have obtained data regarding the importance of ubi- or deubiquitination processes in the control of viral multiplication. We have characterized a viral deubiquitinase (DUB) with very original properties in terms of substrate specificities and protein structure. We are currently studying its structure/function relationship, as well as its effects on cellular protein substrates.
Ivan Dikic

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Institute of Biochemistry II. Goethe University School of Medicine. University Hospital
http://www.biochem2.com
Germany
WG2
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Ubiquitin signalling, autophagy, cancer biology and molecular medicine
Izabela Sumara

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Institute of Genetics and Molecular and Cellular Biology (IGBMC)
http://www.igbmc.fr
France
WG5
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The main goal of our work is to understand the role ubiquitin signaling during mitosis. We study essential components of ubiquitin coding (E3 ligases) and decoding (Ubiquitin receptors) machineries during mitotic progression.
Jacques Neefjes

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Netherlands Cancer Institute. NKI
http://neefix.labstore.nl
Netherlands
WG2
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The Neefjes lab has been working on the cell biology of MHC class I and MHC class II molecules. This also involves the many protease dependent steps required to degrade proteins and peptides for presentation. The Neefjes lab has utilized genome-wide screens (siRNA and gene inactivation) to define new proteins and proteases in the MHC class I and MHC class II pathways and are currently aiming to define their fine-specificity and biochemistry. Neefjes is trained as a chemist and specialized in immunology and cell biology. With the arrival of Prof Dr Huib Ovaa in the Division, Neefjes expanded his interests in applications of chemical biology and immunology. Here chemical tools are used to define biology and that biology is used to better define the compounds. This has yielded new target-new lead combinations for manipulating immune responses.
Janos Terzic

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University of Split. School of Medicine
http://www.mefst.hr
Croatia
WG6
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Speciality on Cancer related research: - Role of inflammation in cancer - DNA repair and cancer - Autophagy (mitophagy, autophagy and cancer) We use all modern molecular biology techniques starting from cell culture experiments, protein and nucleic acid manipulation to animal work. We use different full and conditional knock-out models.
Jasna Bankovic

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Institute for Biological Research Sinisa Stankovic. Laboratory for Molecular Neurobiology
http://www.ibiss.bg.ac.rs
Serbia
WG2
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Speciality: OncologySkills: RNA and DNA isolation, Real-time PCR, Sequencing, Fragment analysis, Cell culture
Jason Brown

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Ubiquigent Limited
http://www.ubiquigent.com
United Kingdom
WG6
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The company develops reagents, kits and services to support both basic and drug discovery applied ubiquitin system research. The company develops HTS assays for screening ubiquitin system targets and offers profiling services for clients to determine the affinity and specificity of their ubiquitin system targeting molecules; for example our DUBprofiler service for profiling the activity of deubiquitylase targeting molecules.
Jean-Ehrland Ricci

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UNICE. INSERM U165. C3M. Centre Méditerranéen de Médecine Moléculaire
http://www.unice.fr
France
WG2
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Regulation of cell death mechanisms in cancers.
Jérôme Kucharczak

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CNRS/Ecole Normale Supérieure de Lyon
http://www.ens-lyon.fr
France
WG2
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Overexpression of bcl-2 and other related prosurvival genes occurs in many human cancers including B-cell lymphomas. Bcl-2 proteins form homo- and hetero-complexes regulating the permeability of the mitochondrial outer membrane. However, twenty-eight years after the discovery of bcl-2, the precise mechanisms which sustain the opposite effects of the various Bcl-2 family members are still under debate. Much of the difficulty of building a coherent model results from : (i) the little experimental data available concerning membrane behavior of these proteins and their interaction with the mitochondrial surface; (ii) limited knowledge of the evolution of the family. Ubiquitination of anti-apoptotic Bfl-1 Role of mitochondria in cellular longevity
Jesús de la Cruz

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University of Seville
http://personal.us.es
Spain

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We make use mainly of the budding yeast Saccharomyces cerevisiae as a model eukaryotic organism. Work in our lab is focused in the following general topics:
Jo Morris

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University of Birmingham
http://www.birmingham.ac.uk
United Kingdom
WG1
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Recent work has focused on the relevance of the small modifier proteins ubiquitin and SUMO in the DNA damage response. The work of Jo Morris showed that SUMO isofoms are part of the DNA repair response and SUMOylation of BRCA1 acts to regulate its ability to act as a ubiquitin ligase. She also showed that the location of the BRCA1 ubiquitin ligase activity in cells?at sites of DNA repair and the recent work of the Morris Laboratory has focused on the enzymes required to clear ubiquitin conjugates from sites of DNA damage repair. Skills: Investigating the impact of changes in small modifier biology on the DNA damage response.
John C Christianson

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Ludwig Institute for Cancer Research at the University of Oxford
http://www.ludwig.ox.ac.uk
United Kingdom
WG4
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Speciality: Mammalian ER-associated degradation and its relation to the unfolded protein response Skills: We are a traditional molecular and cell biology lab with expertise in cell culture, DNA and protein purification, western blotting, radiolabeling, subcellular fractionation and in vitro assays. We also have experience in mass spectrometry and flow cytometry.
John Hohneker

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FORMA Therapeutics
http://www.formatherapeutics.com
USA
WG1
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Deubiquitination, Sumoylation, E-ligases, and Epigenetic readers/writers / erasers and super-enhancers.
Jordi Alcaraz

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Universitat de Barcelona, Unit of Biophysics and Bioengineering
http://www.ub.edu
Spain
WG2
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Our group has technical expertise in cell and molecular biology, and biophysics. Cell and molecular biology skills includes cell culture, 2D and 3D cultures, co-cultures, qRT-PCR, western-blotting, ELISA, invasion assays. Biophysics skills includes optical microscopy (epifluorescence, confocal microscopy), image analysis, Atomic force Microscopy, and manipulation of hydrogels.
Jose Antonio Rodriguez

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University of the Basque Country UPV/EHU
http://www.ehu.es
Spain
WG1
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Our work deals with the function and regulation of human deubiquitinases. In particular, we are interested in the identification and characterization of novel substrates of these enzymes. We also have an interest in elucidating the mechanisms (subcellular localization, interaction with other proteins, etc) that modulate the activity of human DUBs. Our current focus is on two members of the DUB family: USP1 and USP21.
Jose Gonzalez Castaño

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Universidad Autónoma de Madrid
http://www.iib.uam.es
Spain
WG4
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Protein degradation and neurodegneration
José Luis Rosa

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Universitat de Barcelona. IDIBELL
http://www.ub.edu
Spain
WG3
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The main goal our research group is to understand the physiological function of HERC protein family. This family of proteins contains structural domains related with the guanine nucleotide exchange factor RCC1 and the E3-ubiquitin ligases (HECT family). We are focus in the functional characterization of two members of this family: HERC1 and HERC2. We are interested in the signal transduction pathways regulated by these proteins and in their role in neurodegeneration and cancer
Juan Carlos del Pozo Benito

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Centro de Biotecnología y Genómica de Plantas (CBGP)
http://www.cbgp.upm.es
Spain
WG5
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Study of cell cycle and ubiquitin pathway in plants. SCF complexes, hormone signaling, lateral root development
Julien Licchesi

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University of Bath
http://julienlicchesi.wordpress.com
United Kingdom
WG5
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Speciality: Our main research interest focuses on the characterisation of Ubiquitin-mediated mechanisms mediating protein degradation in the context of cell growth and proliferation pathways. We are particularly interested in defining the biochemical properties and cellular functions of OTU deubiquitylases and HECT E3 ubiquitin ligases in normal and disease states. We have also recently become interested in applying our research to the field of neurosciences and in particular neurodegenerative diseases. We use cellular and biochemical techniques as well as structure-function studies of ubiquitin-specific enzymes.Skills: Confocal microscopy, high-content microscopy, flow cytometry, cell cycles assays, protein expression/purification, biochemical and cellular characterisation of ubiquitin-specific enzymes, in vitro ubiquitination assays. Luciferase reporter assay of signal transduction pathway activity, gene expression analysis, Chromatin IP, Methylation-Specific PCR.
Julio Salinas

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Centro de Investigaciones Biologicas-CSIC
http://www.cib.csic.es
Spain
WG1
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Understanding the molecular mechanisms controlling plant responses to adverse environmental conditions.
Kay Hofmann

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Institute for Genetics, University of Cologne
http://www.genetik.uni-koeln.de
Germany
WG1
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Evolution of Proteostasis Pathways, particular focus on recognition of ubiquitin and ubiquitin-like modifiers.
Klaas J. van Wijk

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Cornell University
http://www.cornell.edu
USA
WG2
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Chloroplast biology. Proteases, protein maturation and proteostasis networks in plant organelles. Functional characterization of plastid lipoprotein particles and their function in plant isoprenoid metabolism. Chloroplast differentiation in C4 plant species. Large scale proteomics, mass spectrometry and systems biology in plants.
Konstanze F. Winklhofer

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Institute of Biochemistry and Pathobiochemistry - Ruhr University Bochum
http://www.ruhr-uni-bochum.de
Germany
WG2
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Cellular quality control and stress response pathways linked to neurodegenerative diseases: Ubiquitin signaling and stress protection, Cellular quality control mechanisms to promote protein homeostasis, Mechanisms to maintain mitochondrial integrity and function, Interorganellar communication and its role in the cellular stress response.
Koraljka Husnjak

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Institute of Biochemistry II. Goethe University School of Medicine
http://www.biochem2.com
Germany
WG1
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Speciality: ? role of proteasome ubiquitin receptors in development ? cross-talk between UPS and autophagy ? study of atypical ubiquitin chains, their binding domains and physiological roles Skills: Mouse genetics techniques, cell culture, molecular biology techniques (cloning, yeast two-hybrid), biochemistry (protein purification, in vitro binding assay, in vitro ubiquitination), microscopy, mass spectrometry techniques (interactome, ubiquitination), proteasome activity assays etc.
Kris Gevaert

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VIB-UGent Center for Medical Biotechnology
http://www.vib.be
Belgium
WG1
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Together with Joël Vandekerckhove I have introduced the suite of COFRADIC proteomics technologies which my group applied to the deep analysis of protein modifications, including protein processing by proteases and N-terminal acetylation combined with ribosomal profiling (proteogenomics). Of note, the COFRADIC platform formed the basis for establishing the VIB/UGent spin-off company Pronota that focuses on protein biomarkers for various human diseases (Pronota was merged into MyCartis in 2014). My group published more than 290 papers and several book chapters on the development and applications of proteomics techniques in several areas of biomedical and life sciences research.
Kristiina Irma Helena Himanen

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University of Helsinki. Faculty of Agriculture and Forestry. Department of Agricultural Sciences
http://tuhat.halvi.helsinki.fi
Finland
WG1
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Speciality: : My previous experience has been on the role of ubiquitination of nucleosomal histones in regulation of transcription and thereby plant growth and development. Currently in my own research group we are performing genomic screening of Arabidopsis UPS system to identify molecular networks of E3 ligases involved in flowering time regulation and flower development as well as pathogen responses. This work includes database mining and phenotypic screening of mutant collections, Y2H interaction screens and protein-protein assays. Skills: General molecular biology lab routines, including Y2H, protein purifications (TAP) and enzymatic assays. Plant specific techniques include transgenesis, tissue culture and we are currently building a national infrastructure for automated image based plant phenotyping.
Krisztina Tar

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Department of Medical Chemistry, Faculty of Medicine, University of Debrecen
http://www.medchem.dote.hu
Hungary
WG2
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Proteasome, proteasome activator PA200, mitochondrial activity and dynamics, Huntington’s disease, transglutaminase 2, mitochondrial fission and fusion, Drp1-mitochondrial fission protein.
L. Maria Lois

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Center for Research in Agricultural Genomics CRAG (CSIC-IRTA-UAB)
http://www.cragenomica.es
Spain
WG1
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We are interested in the biochemical characterization of SUMO conjugation machinery in plants and the study of SUMO role in plant development. For this purpose, we use several approaches comprising genetics, proteomics, biochemistry and cell biology.
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