Action Members are any researcher who participates actively in PROTEOSTASIS. All Members belong to one or more Working Group. Members can include researchers from COST Countries, Near Neighbour and International Partner Countries.

Vicente Rubio

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Centro Nacional de Biotecnología-CSIC
http://www.cnb.csic.es
Spain
WG3
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Standard plant molecular biology and genetics techniques. Plant proteomics (TAP purification of protein complexes, 2-D Fluorescence Difference Gel Electrophoresis applied to nuclear proteomics, screeing of plant cDNA libraries by Yeast Two Hybrids), in vitro ubiquitination assays, Affinity purification of ubiquitinated proteins from plant extracts, ?
Viktor Korolchuk

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Newcastle University
No website
United Kingdom
WG2
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Wiep Scheper

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VU University Medical Center
http://www.cncr.nl
Netherlands
WG4
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Molecular analysis of the role of proteostasis in Alzheimer?s disease pathogenesis, using cell and animal models as well as human post-mortem brain material
Xavier Jacq

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MISSION Therapeutics
http://www.missiontherapeutics.com
United Kingdom
WG1
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MISSION Therapeutics is a private drug discovery company focused on elucidating and targeting the ubiquitin pathway to treat cancers and other diseases. The company is developing small molecule drugs that target deubiquitylating enzymes (DUBs) involved in the DNA damage response, with the aim of inducing synthetic lethality, a powerful mechanism to selectively kill specific tumour cells. Our novel DUB technology platform integrates unique biology, screening and chemistry capabilities to rapidly and effectively select and develop compounds targeting DUBs. Skills: Assay development; high throughput screening, biochemical DYUB assays; cellular DUB assays; in vivo DUB assays
Yogesh Kulathu

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MRC Protein Phosphorylation & Ubiquitylation Unit, Universty of Dundee
http://www.ppu.mrc.ac.uk
United Kingdom
WG1
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Mechanistic understanding of ubiquitin signaling – how ubiquitin signals are decoded and regulated. We use a multidisciplinary approach to gain fundamental insights into regulation of cellular processes by ubiquitin signaling.
Yosef Shaul

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Weizmann institute of science
http://www.weizmann.ac.il
Israel
WG2
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Molecular biologist, cell biologist, molecular virologist, signaling, protein modification and proteasomal degradation.
Zdena Palkova

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Charles University in Prague. Faculty of Science
http://web.natur.cuni.cz
Czech Republic
WG2
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Molecular and cellular biology of yeast multicellular populations, colonies. Ammonia signaling, metabolic reprogramming, ageing and cell differentiation in smooth colonies of laboratory strains and in structured biofilm colonies of wild strains. Signaling pathways, transcription regulations and metabolism. In relation to PROTEOSTASIS: i) Function and regulation of autophagy in U cells of differentiated colonies. ii) Function and regulation of proteasomes in colony development. SKILLS: Expertise in techniques related to the investigation of yeast colonies, including separation of differentiated cells, RNA/DNA isolation, confocal microscopy, colony sectioning and others. Expertise in transcriptomics (microarrays), yeast cell manipulation and strain construction (knockout strains, FP labeled strains), cloning, amino acid isolation and quantification, enzymatic assays etc.
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