Action Members are any researcher who participates actively in PROTEOSTASIS. All Members belong to one or more Working Group. Members can include researchers from COST Countries, Near Neighbour and International Partner Countries.

Sulev Kõks

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University of Tartu. Department of Pathophysiology
http://www.biomeditsiin.ut.ee
Estonia
WG6
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Genomics, RNAseq, animal experiments, the function of Wfs1 protein, ER stress in the inflammatory and degeneratiive diseases. We have studied psoriasis in the relation of ER stress and now work on the role of ER stress in the Parkinson disease. Available technologies are: Next generation sequencing, bioinformatics and statistics of NGS results, RNAseq, Exome seq, clinical biobank, animal center with in vivo imaging, transgenic facility.
Susana Seixas

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Genetic Diversity Unit. IPATIMUP
http://www.ipatimup.pt
Portugal
WG3
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Analysis of the genetic variation of proteolysis genes (SERPINs, WFDCs and KLKs) in both healthy and disease individuals. Experimental assessment of gene variants impact in gene expression and regulation, protein folding and molecular pathways. Comparative genomics and evolutionary studies.
Sykiotis Gerasimos

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University Hospital of Lausanne (CHUV)
http://www.chuv.ch
Switzerland
WG6
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My research focuses on the Nrf2 antioxidant response system and its protective roles in different systems and organisms, including flies, mice and humans. Nrf2 is a main convergence point of proteolytic and cell defense systems: it is not only activated by oxidative stress but it also cross-talks with the UPR through its activation by the endoplasmatic reticulum stress-responsive PERK kinase, and with the ALS through the interaction of sequestosome/p62 with the Nrf2 inhibitor Keap1. Moreover, Nrf2 controls the expression not only of antioxidant and detoxification genes but also of multiple proteasome subunits. Thus, Nrf2, which is itself degraded by proteolysis under normal conditions, coordinates the antioxidant response with the UPR and the ALS. My research will benefit from the networking opportunities within Proteostasis to launch new research projects on the relationship between Nrf2, UPR, and ALS signaling. As a practicing physician, I could also participate in clinically relevant projects launched by the Action. Conversely, Action participants will benefit from my expertise on Nrf2 signaling, including the experimental tools for its study at my disposal, which I can distribute freely.Skills: Clinical endocrinology and diabetology (adults, adolescents).Medical genetics and molecular genetic diagnostics.Molecular biology and model organism genetics (flies, mice).Drug discovery and clinical trials.Project evaluation (FP7, Marie Curie)
Sylvie Urbé

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Institute of Translational Medicine. University of Liverpool
http://pcwww.liv.ac.uk
United Kingdom
WG3
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Endocytosis, RTK trafficking and signaling. Deubiquitylation in pathways germane to cancer.
Teresa Rinaldi

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UNIVERSITY OF ROME LA SAPIENZA DIP BIOLOGY and BIOTECHNOLOGY
http://bbcd.bio.uniroma1.it
Italy
WG2
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Speciality: mitochondria and proteasome, CSN complex in yeast. Skills: yeast genetics and cellular biology, fluorescent and confocal microscopy.
Teresa Zoladek

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Institute of Biochemistry and Biophysics Polish Academy of Sciences (IBB PAS)
http://www.ibb.waw.pl
Poland
WG2
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Molecular and cellular genetics and biology of yeast.Studies on the role of Rsp5-dependent ubiquitination of proteins in mechanisms of protein transport via endocytosis, autophagy, Golgi to ER transport.Role of Rsp5-dependent ubiquitination in actin cytoskeleton organization.Role of ubiquitination in tRNA metabolism. Regulation of Rsp5 ubiquitin ligase by phosphorylation. One goal of the newest grant is to find mechanisms which are disturbed in cells by mutations in VPS13A and VPS13B gene corresponding to human inherited diseases, Cohen syndrome and Chorea acanthocytosis, by using yeast as a model organism. Yeast Vps13 protein is involved in Golgi-to vacuole trafficking and was also found in actin cortical patches which are sites of endocytosis. Vps13 protein shows some homology to Atg2 protein involved in autophagy. Another goal is to find function of Atg2 in autophagy.
Theodora Farmaki

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CERTH-INAB
http://inab.certh.gr
Greece
WG2
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1. Study of the role of FKBP chaperones in seed germination under stress conditions (especially salinity). 2. Involvement of FKBP chaperones in autophagy, proteosome and SUMOylation. 3. FKBP interaction with PI3,5P2 and PI3P involved in autophagosome formation. 4. Role of phospholipases in cotton resistance to cold stress and wounding.
Thimo Kurz

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Scottish Institute for Cell Signaling. University of Dundee. SCILLS
http://www.ppu.mrc.ac.uk
United Kingdom
WG1
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My lab focuses on various aspects of the ubiquitin/UBL system. We?re specifically interested in the UBL NEDD8 and how it regulates the largest class of Ubiquitin-ligases, the Cullin-RING E3s. We have also a focus on the role of the ubiquitin system in disease. In particular, we?ve recently focused on the role of a CUL3-based CRL in blood pressure regulation and on the involvement of the ubiquitin-receptor UBQLN2 in neurodegenerative diseases.
Thomas Sommer

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Max-Delbrück-Center for Molecular Medicine and Humboldt-University Berlin
http://www.mdc-berlin.de
Germany
WG1
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Ubiquitin Proteasome Pathway, Protein Quality Control, ERAD, Membrane Protein Complexes
Thorsten Hoppe

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Institute for Genetics and CECAD Cluster of Excellence
http://www.cecad.uni-koeln.de
Germany
WG4
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Speciality:The maintenance of protein homeostasis, or proteostasis, involves the degradation of misfolded and damaged proteins and is essential for cellular function, organismal growth, and ultimately viability. The integrity of the proteome is a long-term challenge not only for individual cells but also for entire organisms since damaged and aggregated proteins accumulate with stress and aging. The ubiquitin/proteasome system (UPS) and autophagy are the major proteolytic routes embedded in a cellular quality control network that ensure efficient turnover of defective proteins. Research in my lab aims to understand proteolytic networks -especially ubiquitin based - in aging and disease. Current projects address proteostasis mechanisms focused on genome stability, protein aggregation diseases and lifespan regulation. Skills: Use of Caenorhabditis elegans as a multicellular organism to study the physiological relevance of proteostasis mechanisms. Techniques include genetic approaches, forward genetic screens, reverse genetics, phenotypic analysis including life span, protein aggregation, muscle degeneration, neuronal function, in vivo degradation assays, biochemistry, time lapse microscopy, in vivo localization, next generation sequencing of genomic DNA, mRNAs, microRNAs.
Thorsten Pfirrmann

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Institute of Physiological Chemistry
http://www.medizin.uni-halle.de
Germany
WG1
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We are mostly interested in UPS components involved in human genetic disease and in early development of Xenopus laevis. My focus lies on Ube3a, Otud3 and the CTLH complex. Additionally, we are studying the impact of protein glycation on proteostasis.
Tiago Fleming Outeiro

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University Medical Center Goettingen (UMG)
http://www.med.uni-goettingen.de
Germany
WG1
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In our work we focus on the study of protein misfolding and aggregation and how this relates to neurodegenerative diseases such as Alzheimer?s, Parkinson?s, or Huntington?s disease. We use a variety of model organisms, from yeast to mouse models, and we employ cell and molecular biology techniques applied to neuroscience. We hold expertise in fluorescence microscopy (high-content imaging, FRAP, STED), molecular biology, lentiviral vector production, primary neuronal cultures, mouse models, protein purification, aggregation assays.
Tijana Stankovic

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Institute for Biological Research “Sinisa Stankovic”
http://www.ibiss.bg.ac.rs
Serbia

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RNA and DNA isolation
Tom Nicholson

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VIVA Bioscience Ltd.
http://www.vivabioscience.com
United Kingdom

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Tommer Ravid

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The Hebrew University of Jerusalem
http://www.bio.huji.ac.il
Israel
WG4
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Speciality: Protein quality control by the ubiquitin-proteasome system. Skills: We use yeast as a model organism, employing a large number of genetic and molecular biology tools. We also employ biochemical and cell biology assays for studying misfolded protein ubiquitylation and degradation, both in vitro and in vivo. We also take a high throughput approach for studying the biochemical properties of misfolded proteins.
Tor Erik Rusten

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Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital
http://www.ous-research.no
Norway
WG6
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Autophagy, Drosophila genetics, human organoid Caco2 culture, Receptor Tyrosine Kinase signaling, phosphatidylinositol kinase signaling, growth control.
Ugo Mayor

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UPV/EHU - University of the Basque Country
http://www.ugomayor.com
Spain
WG6
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Ubiquitination has essential roles in neuronal development, function and disease. Isolation of neuronal ubiquitin conjugates from living organisms has however proven difficult, but we have developed some novel strategies to overcome this.
Ulrich auf dem Keller

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ETH Zurich
http://www.mhs.biol.ethz.ch
Switzerland
WG6
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protease proteomics in tissue repair and regeneration; degradomics method development; Terminal Amine Isotopic Labeling of Substrates Skills: proteomics; degradomics Terminal Amine Isotopic Labeling of Substrates skin cell culture models animal models of wound healing and skin carcinogenesis molecular biology and cell biology
Ute Hoecker

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Botanical Institute Cluster of Excellence on Plant Sciences (CEPLAS)
http://www.botanik.uni-koeln.de
Germany
WG3
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Role of ubiquitination in responses of the plant Arabidopsis thaliana to light (light signal transduction). Study of the E3 ubiquitin ligase COP1/SPA.
Valérie Doye

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Institut Jacques Monod - CNRS - Université Paris Diderot
http://www.ijm.fr
France
WG1
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Our main research focus is the understanding of non-conventional functions of nuclear pore complexes in cell cycle, differentiation and nuclear metabolism. In particular, we are interested in the functional connexions between nuclear pores functions (in particular mRNP export) and SUMOylation.
Vicente Rubio

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Centro Nacional de Biotecnología-CSIC
http://www.cnb.csic.es
Spain
WG3
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Standard plant molecular biology and genetics techniques. Plant proteomics (TAP purification of protein complexes, 2-D Fluorescence Difference Gel Electrophoresis applied to nuclear proteomics, screeing of plant cDNA libraries by Yeast Two Hybrids), in vitro ubiquitination assays, Affinity purification of ubiquitinated proteins from plant extracts, ?
Viktor Korolchuk

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Newcastle University
No website
United Kingdom
WG2
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Wiep Scheper

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VU University Medical Center
http://www.cncr.nl
Netherlands
WG4
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Molecular analysis of the role of proteostasis in Alzheimer?s disease pathogenesis, using cell and animal models as well as human post-mortem brain material
Xavier Jacq

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MISSION Therapeutics
http://www.missiontherapeutics.com
United Kingdom
WG1
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MISSION Therapeutics is a private drug discovery company focused on elucidating and targeting the ubiquitin pathway to treat cancers and other diseases. The company is developing small molecule drugs that target deubiquitylating enzymes (DUBs) involved in the DNA damage response, with the aim of inducing synthetic lethality, a powerful mechanism to selectively kill specific tumour cells. Our novel DUB technology platform integrates unique biology, screening and chemistry capabilities to rapidly and effectively select and develop compounds targeting DUBs. Skills: Assay development; high throughput screening, biochemical DYUB assays; cellular DUB assays; in vivo DUB assays
Yogesh Kulathu

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MRC Protein Phosphorylation & Ubiquitylation Unit, Universty of Dundee
http://www.ppu.mrc.ac.uk
United Kingdom
WG1
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Mechanistic understanding of ubiquitin signaling – how ubiquitin signals are decoded and regulated. We use a multidisciplinary approach to gain fundamental insights into regulation of cellular processes by ubiquitin signaling.
Yosef Shaul

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Weizmann institute of science
http://www.weizmann.ac.il
Israel
WG2
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Molecular biologist, cell biologist, molecular virologist, signaling, protein modification and proteasomal degradation.
Zdena Palkova

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Charles University in Prague. Faculty of Science
http://web.natur.cuni.cz
Czech Republic
WG2
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Molecular and cellular biology of yeast multicellular populations, colonies. Ammonia signaling, metabolic reprogramming, ageing and cell differentiation in smooth colonies of laboratory strains and in structured biofilm colonies of wild strains. Signaling pathways, transcription regulations and metabolism. In relation to PROTEOSTASIS: i) Function and regulation of autophagy in U cells of differentiated colonies. ii) Function and regulation of proteasomes in colony development. SKILLS: Expertise in techniques related to the investigation of yeast colonies, including separation of differentiated cells, RNA/DNA isolation, confocal microscopy, colony sectioning and others. Expertise in transcriptomics (microarrays), yeast cell manipulation and strain construction (knockout strains, FP labeled strains), cloning, amino acid isolation and quantification, enzymatic assays etc.
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