The Management Committee (MC) is the organ at the highest level of decision in the Action. It is composed of 1 or 2 delegates per participant country, nominated by their respective COST National Coordinator (CNC). It is in charge of the coordination, implementation and management of an Action with a view to achieving the Action’s scientific and technological objectives. Delegates will meet twice a year and will have regular communication with the Core Group.

Petek Ballar

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Ege University
http://www.ege.edu.tr
Turkey
WG4
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Ubiquitin mediated proteasomal degradation, Endoplasmic Reticulum associated degradation
Pétur Henry Petersen

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University of Iceland
http://lifvisindi.hi.is
Iceland
WG6
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Speciality: Cell biology of Neurodegenerative diseases. Skills: Work on model organisms Drosophila and the mouse. Gene expression analysis, protein studies. Cell culture.
Rasmus Hartmann-Petersen

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University of Copenhagen
http://www1.bio.ku.dk
Denmark
WG4
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ubiquitin-binding proteins, degradation of misfolded proteins, proteasome-associated proteins
Robert Sarisky

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FORMA Therapeutics
http://www.formatherapeutics.com
USA
WG1
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Deubiquitination, Sumoylation, E-ligases, and Epigenetic readers/writers / erasers and super-enhancers.
Ronald  T Hay

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Wellcome Trust Centre for Gene Regulation and Expression. College of Life Sciences. University of Dundee
http://www.lifesci.dundee.ac.uk
United Kingdom
WG3
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Establishing the role of SUMO modification in the response of cells to DNA damage. Determining the structure and function of the SUMO targeted ubiquitin E3 ligase RNF4. Defining the pathway that leads to degradation of the Promyelocytic Leukaemia protein during arsenic therapy for Acute promyelocytic Leukaemia Investigating the role of SUMO modification in response to proteotoxic stress.
Rosa Barrio

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CIC bioGUNE
http://personal.cicbiogune.es
Spain
WG3
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We investigate biomedically relevant genes and processes using Drosophila melanogaster and mouse as model systems, as well as human cells. We are interested on the role of SUMOylation in development, steroidogenesis, ciliogenesis and growth, through the modification of transcription factors.
Rosa Farràs Rivera

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Centro de Investigación Principe Felipe CIPF
http://www.cipf.es
Spain
WG6
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A major focus of our work is to understand the regulatory mechanisms of protein turnover of cell cycle-related proteins and how these processes impact on proliferation, differentiation and tumorigenesis. This is a critical area of cancer research, since accelerated cell growth and deregulated protein turnover is a major feature of tumour formation and progression. In addition, cellular differentiation is also associated with the regulation of protein turnover and often antagonises carcinogenesis. We believe that a better understanding of the molecular basis of malignant transformation will lead not only to further advances in cancer biology but also to help develop novel and effective cancer therapies.
Rudi Beyaert

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VIB and Ghent University
http://www.vib.be
Belgium
WG3
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With our research we want to contribute to the understanding of molecular signaling mechanisms that control inflammation and immunity. Our current activities are focused mainly on the nuclear factor-kB (NF-kB) signaling pathway, which is activated in response to injury, infection, inflammation and other stressful conditions requiring rapid reprogramming of gene expression. Inappropriate NF-kB dependent gene expression is implicated in the pathogenesis of inflammatory diseases and cancer. We are using several molecular and biochemical approaches to generate fundamental knowledge on signaling mechanisms that control and fine-tune NF-kB activation downstream of specific receptors involved in inflammation and immunity (TNF-R, IL-33R, TLRs, RLRs, TCR). We are also studying a number of other signaling pathways that sometimes crosstalk with NF-kB signaling, such as interferon regulatory factor (IRF) signaling and autophagy. A common theme in our research is the role of ubiquitin-mediated signaling.
Rune Matthiesen

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IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto
http://www.ipatimup.pt
Portugal
WG1
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MS based drug profiling or pharmacoproteomics with the aim of obtaining mechanistic insight into drug function
Simona Polo

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Fondazione IFOM Istituto FIRC di Oncologia Molecolare
http://www.ifom-ieo-campus.it
Italy
WG3
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My major contributions have been on the understanding of how Ub works in the endocytic pathway, with a specific focus at the critical interface between endocytosis/trafficking and intracellular signaling. The results that I have obtained over the past years have contributed to establish new fundamental paradigms: 1) Ubiquitin is an endocytic signal in mammalian cells: 2) Ubiquitin is a signaling molecule 3) Ubiquitin ligase E3s, are regulated by ubiquitination
Steven Tregay

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FORMA Therapeutics
http://www.formatherapeutics.com
USA
WG1
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Deubiquitination, Sumoylation, E-ligases, and Epigenetic readers/writers / erasers and super-enhancers.
Sulev Kõks

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University of Tartu. Department of Pathophysiology
http://www.biomeditsiin.ut.ee
Estonia
WG6
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Genomics, RNAseq, animal experiments, the function of Wfs1 protein, ER stress in the inflammatory and degeneratiive diseases. We have studied psoriasis in the relation of ER stress and now work on the role of ER stress in the Parkinson disease. Available technologies are: Next generation sequencing, bioinformatics and statistics of NGS results, RNAseq, Exome seq, clinical biobank, animal center with in vivo imaging, transgenic facility.
Sykiotis Gerasimos

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University Hospital of Lausanne (CHUV)
http://www.chuv.ch
Switzerland
WG6
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My research focuses on the Nrf2 antioxidant response system and its protective roles in different systems and organisms, including flies, mice and humans. Nrf2 is a main convergence point of proteolytic and cell defense systems: it is not only activated by oxidative stress but it also cross-talks with the UPR through its activation by the endoplasmatic reticulum stress-responsive PERK kinase, and with the ALS through the interaction of sequestosome/p62 with the Nrf2 inhibitor Keap1. Moreover, Nrf2 controls the expression not only of antioxidant and detoxification genes but also of multiple proteasome subunits. Thus, Nrf2, which is itself degraded by proteolysis under normal conditions, coordinates the antioxidant response with the UPR and the ALS. My research will benefit from the networking opportunities within Proteostasis to launch new research projects on the relationship between Nrf2, UPR, and ALS signaling. As a practicing physician, I could also participate in clinically relevant projects launched by the Action. Conversely, Action participants will benefit from my expertise on Nrf2 signaling, including the experimental tools for its study at my disposal, which I can distribute freely.Skills: Clinical endocrinology and diabetology (adults, adolescents).Medical genetics and molecular genetic diagnostics.Molecular biology and model organism genetics (flies, mice).Drug discovery and clinical trials.Project evaluation (FP7, Marie Curie)
Teresa Zoladek

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Institute of Biochemistry and Biophysics Polish Academy of Sciences (IBB PAS)
http://www.ibb.waw.pl
Poland
WG2
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Molecular and cellular genetics and biology of yeast.Studies on the role of Rsp5-dependent ubiquitination of proteins in mechanisms of protein transport via endocytosis, autophagy, Golgi to ER transport.Role of Rsp5-dependent ubiquitination in actin cytoskeleton organization.Role of ubiquitination in tRNA metabolism. Regulation of Rsp5 ubiquitin ligase by phosphorylation. One goal of the newest grant is to find mechanisms which are disturbed in cells by mutations in VPS13A and VPS13B gene corresponding to human inherited diseases, Cohen syndrome and Chorea acanthocytosis, by using yeast as a model organism. Yeast Vps13 protein is involved in Golgi-to vacuole trafficking and was also found in actin cortical patches which are sites of endocytosis. Vps13 protein shows some homology to Atg2 protein involved in autophagy. Another goal is to find function of Atg2 in autophagy.
Tijana Stankovic

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Institute for Biological Research “Sinisa Stankovic”
http://www.ibiss.bg.ac.rs
Serbia

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RNA and DNA isolation
Zdena Palkova

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Charles University in Prague. Faculty of Science
http://web.natur.cuni.cz
Czech Republic
WG2
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Molecular and cellular biology of yeast multicellular populations, colonies. Ammonia signaling, metabolic reprogramming, ageing and cell differentiation in smooth colonies of laboratory strains and in structured biofilm colonies of wild strains. Signaling pathways, transcription regulations and metabolism. In relation to PROTEOSTASIS: i) Function and regulation of autophagy in U cells of differentiated colonies. ii) Function and regulation of proteasomes in colony development. SKILLS: Expertise in techniques related to the investigation of yeast colonies, including separation of differentiated cells, RNA/DNA isolation, confocal microscopy, colony sectioning and others. Expertise in transcriptomics (microarrays), yeast cell manipulation and strain construction (knockout strains, FP labeled strains), cloning, amino acid isolation and quantification, enzymatic assays etc.
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