The Management Committee (MC) is the organ at the highest level of decision in the Action. It is composed of 1 or 2 delegates per participant country, nominated by their respective COST National Coordinator (CNC). It is in charge of the coordination, implementation and management of an Action with a view to achieving the Action’s scientific and technological objectives. Delegates will meet twice a year and will have regular communication with the Core Group.

Gemma Marfany

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Universitat de Barcelona. UB
http://www.ub.edu
Spain
WG6
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We are geneticists besides being molecular biologists. We actively search for genes involved in human hereditary visual diseases causing blindness. Another of our research lines is the characterization of the expression and function of deubiquitinating and SUMO-metabolism enzymes in the retina.
Germana Meroni

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Cluster in Biomedicine (CBM). AREA Science Park / Burlo Garofolo Hospitale
http://www.cbm.fvg.it
Italy
WG1
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Study of the TRIM family of RING-E3 ubiquitin ligases using: i) a systematic genomic and biochemical approaches and ii) a focused study on TRIM members implicated in genetic disorders.
Harald Stenmark

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The Norwegian Radium Hospital
http://www.ous-research.no
Norway
WG2
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Basic cell biology with emphasis on endocytosis, autophagy and cytokinesis as potential tumour suppressor mechanisms. Molecular biology or Rab GTPases and PI 3-kinases. Mammalian cell culture and Drosophila models.
Henrique Girao

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IBILI-Institute of Biomedical Imaging and Life Sciences
http://www.uc.pt
Portugal
WG3
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We have been interested on the molecular mechanisms involved in the maintenance of quality control, with particular focus on non-canonical functions of ubiquitin on lysosomal degradation. For this purpose, we have been studying two main substrates, the HIF1-a, on the context of hypoxia-induced neovascularization, and CxIn our lab routine we use mammalian cell and organ cultures, biochemical techniques, protein manipulation (including overexpression and silencing), confocal and transmission electron microscopy43, involved in gap junction intercellular communication, on the context of heart diseases. In more detail, we have been using these proteins to evaluate the putative crosstalk between proteasome and autophagy, and autophagy and endocytosis
Huib Ovaa

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Leiden University Medical Center (LUMC)
http://research.nki.nl
Netherlands
WG2
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Current research in the Chemical Biology group aims at the development of tools to investigate biochemical processes in relation to cancer. The group plays a leading role in the development of techniques to profile cellular enzymatic activities associated primarily with ubiquitin and ubiquitin-like systems as well as proteasome activity. We use an organic synthesis and mass spectrometry driven approach in order to gain further understanding of the biochemical processes under investigation. The aim is to create diagnostic tools and small molecule modulators of enzymatic properties for the detection and treatment of cancer respectively, well in line with the current consortium goals. Our method is pragmatic; we focus on the search for inhibitors of enzymatic activities by high and ultra-throughput screening of small molecule libraries followed by lead-optimization and on the development of biochemical tools by rational design. Key techniques covered are: organic synthesis in classical and parallel formats, classical biochemistry, high and ultra-throughput screening and fluorescence-based technologies. The group generally applies whatever method fits the needs best for follow-up investigations using innovative tools that are developed in-house.
Isabelle Jupin

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Virologie Moleculaire. Institut Jacques Monod. UMR 7592 CNRS - Universite Paris 7
http://www.ijm.fr
France
WG1
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Our main research interest concerns the molecular mechanisms of viral RNA replication. Lately, we have obtained data regarding the importance of ubi- or deubiquitination processes in the control of viral multiplication. We have characterized a viral deubiquitinase (DUB) with very original properties in terms of substrate specificities and protein structure. We are currently studying its structure/function relationship, as well as its effects on cellular protein substrates.
Ivan Dikic

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Institute of Biochemistry II. Goethe University School of Medicine. University Hospital
http://www.biochem2.com
Germany
WG2
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Ubiquitin signalling, autophagy, cancer biology and molecular medicine
Janos Terzic

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University of Split. School of Medicine
http://www.mefst.hr
Croatia
WG6
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Speciality on Cancer related research: - Role of inflammation in cancer - DNA repair and cancer - Autophagy (mitophagy, autophagy and cancer) We use all modern molecular biology techniques starting from cell culture experiments, protein and nucleic acid manipulation to animal work. We use different full and conditional knock-out models.
Jasna Bankovic

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Institute for Biological Research Sinisa Stankovic. Laboratory for Molecular Neurobiology
http://www.ibiss.bg.ac.rs
Serbia
WG2
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Speciality: OncologySkills: RNA and DNA isolation, Real-time PCR, Sequencing, Fragment analysis, Cell culture
John Hohneker

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FORMA Therapeutics
http://www.formatherapeutics.com
USA
WG1
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Deubiquitination, Sumoylation, E-ligases, and Epigenetic readers/writers / erasers and super-enhancers.
Libuse Vachova

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Institute of Microbiology of the ASCR. v.v.i.
http://www.biomed.cas.cz
Czech Republic
WG2
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During doctoral studies and after defending PhD (focused on protein turnover in Bacillus megaterium), L. Vachova was involved in investigation of protein turnover, extracellular and intracellular proteases in bacilli and effect of heat and oxidative stress. Current orientation: effect of defense mechanisms and ROS in resistance/survival of yeast multicellular populations, role of low-molecular weight signaling molecules, metabolism and selected organelles in cell adaptation and cell longevity during yeast population development. In relation to PROTEOSTASIS: i) Function and regulation of proteasomes in colony development. ii) Function and regulation of autophagy in U cells of differentiated colonies. SKILLS: Expertise in preparation of genetically modified yeast strains, analyses of stress defense mechanisms, cell fractionation and protein analysis including selected protein modifications, enzymatic assays and immunoassays, analysis of ROS in situ in cells, experience in wide field-, fluorescence-, 2P confocal- and electron microscopy.
Lucian Stoica

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Institute for Cardiovascular Diseases Prof. Dr. George I.M. Georgescu. city of Iasi. Romania
http://www.cardioiasi.ro
Romania
WG2
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Speciality: Cardiovascular Surgery with special interests in all arterial CABG, mitral plasty, aneurysm surgery. I have a PhD thesis on pulmonary atresia with ventricular septal defect. I am interest in new biomarkers and in apoptosis in cardiac surgery in correlation with myocardial protection during the cardiac arrest in cardiac surgery.Skills: All kind of surgical operation in cardiac surgery of the adult and children, in vascular surgery, personal surgical technics in coronary artery surgery, personal web page about coronary artery disease, vascular endoprosthesis implants, experience in postoperative cardiac surgery intensive care, experimental surgery on animals in my field, medical statistics, experience in clinical trials, scientific articles elaboration with publication in USA and Europeans journals with important impact factors
Maria Grazia Masucci

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Karolinska Institutet
http://ki.se
Sweden
WG1
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Tumor viruses, regulation of Ub and UbL cross-talk
Michael Glickman

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Technion
No website
Israel
WG2
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Current research topics 1) Proteasome structure and function, 2) Proteomic charting the cellular ubiquitin-linkage profile 3) Reciprocal relationship between ubiquitination-dependent-degradation and mitochondria function and dynamics. 4) Recognition of ubiquitin and ubiquitin-like signals
Michael John Clague

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University of Liverpool
http://pcwww.liv.ac.uk
United Kingdom
WG3
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Endocytosis, RTK trafficking and signaling. Deubiquitylation in pathways germane to cancer
Nico Dantuma

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Karolinska Institutet
http://twitter.com
Sweden
WG1
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Developing reporter assays for ubiquitin-dependent proteolysis Understanding basic principles of the ubiquitin/proteasome system The ubiquitin/proteasome system in neurodegenerative disorders Ubiquitin signaling in the DNA damage response
Nicolas Thomä

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Friedrich Miescher Institute for Biomedical Researc
http://www.fmi.ch
Switzerland
WG2
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Structure and function studies of large macromolecular assemblies involved in ubiquitination and genome maintenance
Niki Chondrogianni

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National Hellenic Research Foundation
No website
Greece
WG2
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1. Proteasome expression and function during the progression of aging in vitro (replicative senescence model), in vivo (human cohorts and C. elegans) and in age-related diseases. 2. Nrf2 regulation and function Cell culture, C. elegans cultures, Bacterial cultures, Conventional and Real-Time PCR, Cloning, Transformation, Transfection, 1D and 2D protein electrophoresis, Western blot, Immunoprecipitation, Gel filtration analysis, Microscopy, Proteasome activities assay, in-gel assays, Native gel electrophoresis, Oxidized proteins assay, Reactive Oxygen Species (ROS) detection, Lifespan assays in cell cultures and cultures of C. elegans
Olivier Coux

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CRBM (Macromolecular Biochemistry Research Centre). CNRS. UMR 5238
http://www.crbm.cnrs.fr
France
WG2
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Cell biology and biochemical approaches to dissect many aspects of the specificity and mechanism of action of the ubiquitin-proteasome system, in the context of cell cycle
Petek Ballar

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Ege University
http://www.ege.edu.tr
Turkey
WG4
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Ubiquitin mediated proteasomal degradation, Endoplasmic Reticulum associated degradation
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