Action Members are any researcher who participates actively in PROTEOSTASIS. All Members belong to one or more Working Group. Members can include researchers from COST Countries, Near Neighbour and International Partner Countries.
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Krisztina Tar Please log-in to see email and phone. |
Department of Medical Chemistry, Faculty of Medicine, University of Debrecen http://www.medchem.dote.hu Hungary |
WG2 |
| Proteasome, proteasome activator PA200, mitochondrial activity and dynamics, Huntingtons disease, transglutaminase 2, mitochondrial fission and fusion, Drp1-mitochondrial fission protein. | |||
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L. Maria Lois Please log-in to see email and phone. |
Center for Research in Agricultural Genomics CRAG (CSIC-IRTA-UAB) http://www.cragenomica.es Spain |
WG1 |
| We are interested in the biochemical characterization of SUMO conjugation machinery in plants and the study of SUMO role in plant development. For this purpose, we use several approaches comprising genetics, proteomics, biochemistry and cell biology. | |||
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[email protected] Please log-in to see email and phone. |
No website |
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[email protected] Please log-in to see email and phone. |
Leibniz Institute of Plant Biochemistry http://www.ipb-halle.de Germany |
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| Hormone Sensing & signal transduction Plant Biochemistry Ubiquitin & Proteostasis | |||
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Libuse Vachova Please log-in to see email and phone. |
Institute of Microbiology of the ASCR. v.v.i. http://www.biomed.cas.cz Czech Republic |
WG2 |
| During doctoral studies and after defending PhD (focused on protein turnover in Bacillus megaterium), L. Vachova was involved in investigation of protein turnover, extracellular and intracellular proteases in bacilli and effect of heat and oxidative stress. Current orientation: effect of defense mechanisms and ROS in resistance/survival of yeast multicellular populations, role of low-molecular weight signaling molecules, metabolism and selected organelles in cell adaptation and cell longevity during yeast population development. In relation to PROTEOSTASIS: i) Function and regulation of proteasomes in colony development. ii) Function and regulation of autophagy in U cells of differentiated colonies. SKILLS: Expertise in preparation of genetically modified yeast strains, analyses of stress defense mechanisms, cell fractionation and protein analysis including selected protein modifications, enzymatic assays and immunoassays, analysis of ROS in situ in cells, experience in wide field-, fluorescence-, 2P confocal- and electron microscopy. | |||
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Lionel Pintard Please log-in to see email and phone. |
Institut Jacques Monod - CNRS - Université Paris Diderot http://www.ijm.fr France |
WG5 |
| Protein degradation in cell cycle control and differentiation during C. elegans development | |||
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Lionel Pochet Please log-in to see email and phone. |
University of Namur http://www.namedic.be Belgium |
WG6 |
| Speciality: The research centre Namedic (www.namedic.be) is devoted to medicinal chemistry. The activities are highly multidisciplinary, involving in particular the research of new hits, the design of computer-aided drug, organic synthesis of new molecules, the pharmaceutical analysis and the pharmacology. In this research centre, I am particularly interested in the development of new serine protease inhibitors. Skills: Medicinal chemistry with skills in hit discovery, analytical and organic chemistry and enzymatic assay. | |||
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Lucia De Franceschi Please log-in to see email and phone. |
Dept. OF MEDIINE. UNIVERSITY OF VERONA http://lurm.it Italy |
WG3 |
| Cell signaling, oxidation related signaling, plasmebrane network, role of chorein VPS13a in erythroid cells, erythropoiesis, protein-protein interaction in pathological red cell cells Tyrosine cell signaling transduction mainly involving Src family kinase, phosphoroteome analysis, functional proteomics, cell culture, analysis of erythroid cells (red cells and erythropoiesis ) in mouse models | |||
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Lucian Stoica Please log-in to see email and phone. |
Institute for Cardiovascular Diseases Prof. Dr. George I.M. Georgescu. city of Iasi. Romania http://www.cardioiasi.ro Romania |
WG2 |
| Speciality: Cardiovascular Surgery with special interests in all arterial CABG, mitral plasty, aneurysm surgery. I have a PhD thesis on pulmonary atresia with ventricular septal defect. I am interest in new biomarkers and in apoptosis in cardiac surgery in correlation with myocardial protection during the cardiac arrest in cardiac surgery.Skills: All kind of surgical operation in cardiac surgery of the adult and children, in vascular surgery, personal surgical technics in coronary artery surgery, personal web page about coronary artery disease, vascular endoprosthesis implants, experience in postoperative cardiac surgery intensive care, experimental surgery on animals in my field, medical statistics, experience in clinical trials, scientific articles elaboration with publication in USA and Europeans journals with important impact factors | |||
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Luis C Anton Please log-in to see email and phone. |
Centro de Biologia Molecular Severo Ochoa. CBMSO-CSIC http://web4.cbm.uam.es Spain |
WG2 |
| Deregulation of tumor cell proteostasis by protease inhibitors affecting regulatory checkpoints in the Ubiquitin-Proteasome System and Autophagy. Intraellular proteolytic and protein trafficking pathways in TAP-independent MHC class I antigen processing | |||
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Luminita Paduraru Please log-in to see email and phone. |
UNIVERSITY OF MEDICINE AND PHARMACY Gr.T.Popa. IASI. Department of Mother and Child. NEONATOLOGY. Neonatal Intensive Care Unit. Clinical Maternity Hospital of Obstetrics and Gynecology Cuza-Voda. Iasi. ROMANIA http://www.umfiasi.ro Romania |
WG6 |
| Speciality:Clinical paediatrician-neonatologist.Skills: Paediatricion-neonatologist, lecturer in Neonatology, trainer in Neonatal resuscitation and STABLE program. Competence in ecography, mostly transfontanelar ultrasound. | |||
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Luz Irina A. Calderón Villalobos Please log-in to see email and phone. |
IPB-Leibniz Institute of Plant Biochemistry http://www.ipb-halle.de Germany |
WG1 |
| Small Molecule-Mediated Protein Degradation in Plants | |||
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Manuel Rodríguez Please log-in to see email and phone. |
CNRS - ITAV USR3505 http://www.cnrs.fr France |
WG1 |
| Our group has recently developed molecular traps to capture endogenous proteins modified by members of the ubiquitin family. The prototype traps named TUBEs (for Tandem Ubiquitin Binding Entities) capture ubiquitylated proteins from cells, tissues and organs. When associated to mass spectrometry, total ubiquitylated proteins can be captured after a treatment or during a physiological or pathological process. A pattern of ubiquitylation can be associated to particular responses providing biomarkers and potential drug targets. | |||
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Marc Brehme Please log-in to see email and phone. |
Joint Research Center for Computational Biomedicine (JRC-COMBINE), RWTH Aachen University http://www.combine.rwth-aachen.de Germany |
WG6 |
| My research group pursues interdisciplinary approaches to disease modeling at the interface of systems biology, clinical research, and integrative data analysis towards laboratory testable hypotheses and computational disease models with translational potential. The PIs focus and core expertise is on interactome network modeling. A core interest is on proteostasis systems biology and the understanding the proteostasis network (PN) and its alterations in human diseases at a systems level, towards novel mechanistic hypotheses, clinically translatable markers, and rationales for therapeutic network re-adjustment in proteostatis disorders using proteostasis regulator drugs. | |||
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Marc Piechaczyk Please log-in to see email and phone. |
Institut de Génétique Moléculaire de Montpellier. CNRS http://www.igmm.cnrs.fr France |
WG6 |
| We are aiming at both better understanding the mechanisms of oncogenesis and improving anticancer treatments. Most pertinent in the frame of this COST application, we are studying (i) how ubiquitylation/sumoylation/degration of the ubiquitous AP-1 transcription complex contribute to tumorigenesis and (ii) how the ROS/SUMO axis contribute to resistance of certain leukemia to chemotherapy. In the latter case, our work partly rely on a mouse model that also permit to improve monoclonal antibody-based anticancer treatments, leading us to investigate AP-1 and sumoylation in immune cells. | |||
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Marco Trujillo Please log-in to see email and phone. |
Leibniz Institute of Plant Biochemistry http://www.ipb-halle.de Germany |
WG3 |
| Our group is mainly interested in elucidating functions of ubiquitination in plant immunity. We identified and characterization a group of U-box type E3 ligases that negatively regulate immune signaling and are investigating the mechanisms involved in their regulation. We have successfully identified various substrates and thus new components of the immune response. Recent efforts have focused on the analysis E2s-E3 pairing mechanisms and their function in immune signaling in addition to synthetic biology approaches to study mechanisms of ubiquitination. Main skills: -Various plant transient and stable expression systems -Protein expression and purification in E. coli, ubiquitination assays, pull-downs, CoIPS -pathogen assays (bacteria, oomycetes and fungi), immunity bioassays -cell-biological analysis of fusion proteins, colocalization analysis, FRET-FLIM | |||
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Marcus Groettrup Please log-in to see email and phone. |
University of Konstanz http://cms.uni-konstanz.de Germany |
WG1 |
| Research on the immunoproteasome and the ubiquitin-like modifier FAT10 | |||
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Margot Thome Please log-in to see email and phone. |
University of Lausanne. Department of Biochemistry http://www.unil.ch Switzerland |
WG3 |
| Speciality: Molecular analysis of signaling pathways that control lymphocyte activation and lymphomagenesis. Skills: Biochemistry, molecular biology, cell biology, cellular and mouse immunology | |||
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Margret Helga Ogmundsdottir Please log-in to see email and phone. |
University of Iceland, Faculty of Medicine http://lifvisindi.hi.is Iceland |
WG2 |
| The goal of our lab is to understand the complex role of autophagy in cancer. This degradation process has been shown beneficial for cancer cells to cope with stressful environment, however, autophagy has also been shown to have a tumor preventive role. Our current projects are (1) Analyzing the role of autophagy in tumor initiation using patient data and cell culture models, and (2) Analyzing the transcriptional regulation of autophagy in melanoma. | |||
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Maria Grazia Masucci Please log-in to see email and phone. |
Karolinska Institutet http://ki.se Sweden |
WG1 |
| Tumor viruses, regulation of Ub and UbL cross-talk | |||
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Marie-Odile Fauvarque Please log-in to see email and phone. |
Institute for life sciences research and technologies, CEA-Grenoble http://irtsv.cea.fr France |
WG3 |
| The team develops genetics and chemogenomics approaches for the understanding and targeting of ubiquitin proteases function in innate immune response and inflammation. Functional studies of ubiquitin proteases are pursued in living Drosophila fruit flies either in the regulation of NF-kB dependent pro-inflammatory signals or in the regulation of autophagy and intracellular trafficking of plasma membrane receptors, in a living organism. Beside, automated assays are developed for the identification of ubiquitin proteases inhibitors interfering with inflammation or tumorigenesis. In addition to their therapeutic potential, these small molecules present many advantages for research purposes. They are irreplaceable tools for probing dynamic phenomena and inducing reversible effects in the ubiquitin proteasome system. | |||
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Marilin Ivask Please log-in to see email and phone. |
Institute of Biomedicine and Translational Medicine, University of Tartu http://www.biomeditsiin.ut.ee United Kingdom |
WG6 |
| My work is focused on Wolfram syndrome caused by the mutations in the Wfs1 gene. I am studying a WFS1-deficient mouse model created in our University, specializing in ER stress and insulin secretion. In addition, in collaboration with Estonian University of Life Sciences I am working with bovine somatic cell nuclear transfer and embryo technology. | |||
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Mario Durán-Prado Please log-in to see email and phone. |
University of Castilla-La Mancha. Faculty of Medicine http://www.crib.uclm.es Spain |
WG2 |
| Speciality: Neurosciences (Neurodegeneration and neuro-oncology). Our group is focused in the interplay between the redox balance, metabolic reprogramming, proliferation, senescence, apoptosis and autophagy in neuro-oncology and in vascular degeneration associated to Alzheimer`s disease, in vitro and in vivo. Skills: Molecular biology/biochemistry: cloning, RT-PCR, electrophoresis, western, and OMICs. Cell biology/related: Culture of primary and cell lines, transfection, ICC and IHC, quantitative and time-lapse imaging, FRET, cell flow cytometry (apoptosis, cell cycle), etc. Animals: atherosclerosis and orthotopic/xenograft for glioblastoma, breast cancer and melanoma. | |||
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Mario García-Domínguez Please log-in to see email and phone. |
CABIMER-CSIC http://www.cabimer.es Spain |
WG1 |
| Cell differentiation: chromatin adaptors and Sumo posttranslational modification. | |||
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Martin S. Denzel Please log-in to see email and phone. |
Max Planck Institute for Biology of Ageing http://www.denzellab.com Germany |
WG4 |
| We use diverse forward genetic approaches to investigate mechanisms of protein quality control and ageing. Our models are C. elegans and mammalian cells, including embryonic stem cells, and mice. | |||
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Martine Biard-Piechaczyk Please log-in to see email and phone. |
CPBS UMR 5236 CNRS University of Montpellier http://www.cpbs.cnrs.fr France |
WG2 |
| The team is working on the role of autophagy during HIV-1 infection. Autophagy is a major route of degradation and recycling of cytoplasmic constituents. It has been identified as a mechanism of innate immunity activated during infections to eliminate intracellular pathogens. Many pathogens, including viruses, have thus evolved to inhibit, subvert or use autophagy for their own replication. HIV-1, as many other viruses, manipulates, subverts and/or exploits the two proteolytic pathways, UPS and autophagy, as well as the host ubiquitin (Ub) and Ubiquitin-like (UbL) conjugation systems, mainly for its own benefit. We have demonstrated that (i) HIV envelope-mediated apoptosis of the uninfected CD4 T cells, a key feature of HIV-1 pathogenesis, depends on autophagy, (ii) autophagy and Atgs play an essential but complex role in HIV-1 replication, and (iii) Env-mediated autophagy is a cell type-dependent mechanism. Autophagy has thus a central role during HIV-1 infection by governing both the immune cell fate and the course of the disease, suggesting that pharmacological intervention to modulate autophagy may help delay or prevent development of clinical AIDS. | |||
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Matthias Peter Please log-in to see email and phone. |
ETH Zurich (Swiss Institute of Science and Technology Zurich) http://www.bc.biol.ethz.ch Switzerland |
WG4 |
| Matthias Peter is full Professor for Biochemistry at the ETH Zürich since 2002 and currently chair of the Institute of Biochemistry. His research group uses an interdisciplinary approach to investigate the basic mechanisms that govern cell growth and division in yeast and mammalian cells. In particular, he is focused on understanding mechanisms that control selective degradation of key regulators, excess or damaged organelles or protein complexes by the ubiquitin-proteasome-system (UPS) or autophagy. | |||
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Mehmet Murat Koseoglu Please log-in to see email and phone. |
Fatih University http://fatih.edu.tr Turkey |
WG5 |
| Cell culture, mammalian cell synchronization, neuronal differentiation protocols, cloning, site directed mutagenesis, bacterial protein expression and purification, in vitro kinase assays, pull downs, western, coimmunoprecipitation, fluorocent microscopy, Flow Cytometry Analysis, PI staining, BrDU incorporation and apoptotic assays. | |||
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Micha Dadlez Please log-in to see email and phone. |
Mass Spectrometry Laboratory. IBB PAS. ul. Pawi skiego 5A. 02-106 Warsaw http://mslab-ibb.pl Poland |
WG1 |
| Speciality: Mass spectrometry based proteomics, including structural studies.Skills: - Quantitative proteomics using label free and label based approaches- PTM identification and localization- Protein structural studies using Proton/Deuterium Exchange, Ion Mobility, Cross-Linking, Oxidative Footprinting | |||
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Michael Glickman Please log-in to see email and phone. |
Technion No website Israel |
WG2 |
| Current research topics 1) Proteasome structure and function, 2) Proteomic charting the cellular ubiquitin-linkage profile 3) Reciprocal relationship between ubiquitination-dependent-degradation and mitochondria function and dynamics. 4) Recognition of ubiquitin and ubiquitin-like signals | |||