Action Members are any researcher who participates actively in PROTEOSTASIS. All Members belong to one or more Working Group. Members can include researchers from COST Countries, Near Neighbour and International Partner Countries.
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Tor Erik Rusten Please log-in to see email and phone. |
Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital http://www.ous-research.no Norway |
WG6 |
| Autophagy, Drosophila genetics, human organoid Caco2 culture, Receptor Tyrosine Kinase signaling, phosphatidylinositol kinase signaling, growth control. | |||
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Ugo Mayor Please log-in to see email and phone. |
UPV/EHU - University of the Basque Country http://www.ugomayor.com Spain |
WG6 |
| Ubiquitination has essential roles in neuronal development, function and disease. Isolation of neuronal ubiquitin conjugates from living organisms has however proven difficult, but we have developed some novel strategies to overcome this. | |||
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Ulrich auf dem Keller Please log-in to see email and phone. |
ETH Zurich http://www.mhs.biol.ethz.ch Switzerland |
WG6 |
| protease proteomics in tissue repair and regeneration; degradomics method development; Terminal Amine Isotopic Labeling of Substrates Skills: proteomics; degradomics Terminal Amine Isotopic Labeling of Substrates skin cell culture models animal models of wound healing and skin carcinogenesis molecular biology and cell biology | |||
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Ute Hoecker Please log-in to see email and phone. |
Botanical Institute Cluster of Excellence on Plant Sciences (CEPLAS) http://www.botanik.uni-koeln.de Germany |
WG3 |
| Role of ubiquitination in responses of the plant Arabidopsis thaliana to light (light signal transduction). Study of the E3 ubiquitin ligase COP1/SPA. | |||
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Valérie Doye Please log-in to see email and phone. |
Institut Jacques Monod - CNRS - Université Paris Diderot http://www.ijm.fr France |
WG1 |
| Our main research focus is the understanding of non-conventional functions of nuclear pore complexes in cell cycle, differentiation and nuclear metabolism. In particular, we are interested in the functional connexions between nuclear pores functions (in particular mRNP export) and SUMOylation. | |||
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Vicente Rubio Please log-in to see email and phone. |
Centro Nacional de Biotecnología-CSIC http://www.cnb.csic.es Spain |
WG3 |
| Standard plant molecular biology and genetics techniques. Plant proteomics (TAP purification of protein complexes, 2-D Fluorescence Difference Gel Electrophoresis applied to nuclear proteomics, screeing of plant cDNA libraries by Yeast Two Hybrids), in vitro ubiquitination assays, Affinity purification of ubiquitinated proteins from plant extracts, ? | |||
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Viktor Korolchuk Please log-in to see email and phone. |
Newcastle University No website United Kingdom |
WG2 |
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we have shown that one of the branches of the upr Please log-in to see email and phone. |
No website |
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Wiep Scheper Please log-in to see email and phone. |
VU University Medical Center http://www.cncr.nl Netherlands |
WG4 |
| Molecular analysis of the role of proteostasis in Alzheimer?s disease pathogenesis, using cell and animal models as well as human post-mortem brain material | |||
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Xavier Jacq Please log-in to see email and phone. |
MISSION Therapeutics http://www.missiontherapeutics.com United Kingdom |
WG1 |
| MISSION Therapeutics is a private drug discovery company focused on elucidating and targeting the ubiquitin pathway to treat cancers and other diseases. The company is developing small molecule drugs that target deubiquitylating enzymes (DUBs) involved in the DNA damage response, with the aim of inducing synthetic lethality, a powerful mechanism to selectively kill specific tumour cells. Our novel DUB technology platform integrates unique biology, screening and chemistry capabilities to rapidly and effectively select and develop compounds targeting DUBs. Skills: Assay development; high throughput screening, biochemical DYUB assays; cellular DUB assays; in vivo DUB assays | |||
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Yogesh Kulathu Please log-in to see email and phone. |
MRC Protein Phosphorylation & Ubiquitylation Unit, Universty of Dundee http://www.ppu.mrc.ac.uk United Kingdom |
WG1 |
| Mechanistic understanding of ubiquitin signaling how ubiquitin signals are decoded and regulated. We use a multidisciplinary approach to gain fundamental insights into regulation of cellular processes by ubiquitin signaling. | |||
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Yosef Shaul Please log-in to see email and phone. |
Weizmann institute of science http://www.weizmann.ac.il Israel |
WG2 |
| Molecular biologist, cell biologist, molecular virologist, signaling, protein modification and proteasomal degradation. | |||
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Zdena Palkova Please log-in to see email and phone. |
Charles University in Prague. Faculty of Science http://web.natur.cuni.cz Czech Republic |
WG2 |
| Molecular and cellular biology of yeast multicellular populations, colonies. Ammonia signaling, metabolic reprogramming, ageing and cell differentiation in smooth colonies of laboratory strains and in structured biofilm colonies of wild strains. Signaling pathways, transcription regulations and metabolism. In relation to PROTEOSTASIS: i) Function and regulation of autophagy in U cells of differentiated colonies. ii) Function and regulation of proteasomes in colony development. SKILLS: Expertise in techniques related to the investigation of yeast colonies, including separation of differentiated cells, RNA/DNA isolation, confocal microscopy, colony sectioning and others. Expertise in transcriptomics (microarrays), yeast cell manipulation and strain construction (knockout strains, FP labeled strains), cloning, amino acid isolation and quantification, enzymatic assays etc. | |||