Action Members are any researcher who participates actively in PROTEOSTASIS. All Members belong to one or more Working Group. Members can include researchers from COST Countries, Near Neighbour and International Partner Countries.
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Adrian Danek Please log-in to see email and phone. |
Neurologische Klinik. Ludwig-Maximilians-Universität http://www.e-rare.eu Germany |
WG6 |
| Diagnosis and treatment of neurodegenerative brain disease | |||
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Adrienne Gorman Please log-in to see email and phone. |
National University of Ireland. Galway http://www.nuigalway.ie Ireland |
WG4 |
| Speciality: Previous and ongoing research in my group is in the area of stress responses, including the unfolded protein response and heat shock responses. Both of these play a role in promoting cell survival in the face of disruption to cellular proteostasis. Other ongoing research is in the area of cell death, particularly apoptosis, where there is activation of proteolytic pathways (mainly the caspase cascade) that mediate degradation of cellular proteins. Recent published work from my group shows a novel mechanism implicating lysosomal degradation of active caspase proteases that is induced by a pro-survival growth factor. Skills: Biochemistry, cell biology, molecular biology | |||
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Agnieszka Sirko Please log-in to see email and phone. |
Institute of Biochemistry and Biophysiscs http://www.ibb.waw.pl Poland |
WG2 |
| Selective autophagy in plants and its role in plant response to environmental stresses (with focus on nutrient deficiency). Molecular mechanisms responsible for signaling and regulation of plant response to nutrient deficiency stress and other abiotic stresses (with focus on the role of posttranslational processes). Regulation of plant response to sulfur deficiency. DNA vaccines, vaccines against influenza virus (with main focus on birds) | |||
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Alberto Ferrús Please log-in to see email and phone. |
Instituto Cajal. CSIC http://www.ferrus-flysynapse.es Spain |
WG3 |
| Genetic and functional studies of Drosophila synapses under normal and pathological conditions. In particular, under the genetically driven expression of human beta amyloid peptides. | |||
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Alfred C.O. Vertegaal Please log-in to see email and phone. |
Molecular Cell Biology. Leiden University Medical Center http://www.lumc.nl Netherlands |
WG1 |
| Our group is interested in protein SUMOylation, a post-translational modification that predominantly regulates nuclear processes including transcription and the DNA damage response. We use protein purification and mass spectrometry to obtain system-wide insight in SUMO- and also ubiquitin signaling in response to different stimuli. We have developed different purification procedures to obtain system-wide insight in protein SUMOylation and ubiquitination. Novel site-specific methods are being developed. Using quantitative proteomics, we are studying SUMOylation dynamics upon DNA damage. Selected novel SUMO targets are studied at the functional and mechanistic level. | |||
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Alicia Alonso Please log-in to see email and phone. |
University of the Basque Country UPV/EHU. CSIC http://www.unidaddebiofisica.org Spain |
WG2 |
| Membrane biophysics. Model membranes. Protein-lipid interactions. Autophagy. | |||
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Amir Oryan Please log-in to see email and phone. |
Technion http://www.technioncancer.co.il Israel |
WG5 |
| Role of SUMO and ubiquitin signaling in adult tissue homeostasis focusing on adult gut, innate immunity. Impact of Ub/UbL on development and cancer. Specific focus on the Role of SUMO-Targeted ubiquitin ligases in development and cancer. | |||
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Amir Sapir Please log-in to see email and phone. |
No website Israel |
WG2 |
| Speciality: I have established the Nematode C. elegans as a genetic and proteomic platform to study the regulation of the mevalonate pathway that is critical for cholesterol biosynthesis as well as for the synthesis of metabolites required for small GTPase protein activation and cellular respiration. We discovered a previously unknown regulatory circuit that controls the sumoylation and ubiquitination levels of the first enzyme in the pathway, HMGCS1. We further characterized this circuit and found how it is regulated temporally by an age-dependent cytosol-to-mitochondria sorting of specific circuit components. Recently, we have found a strong connection between mitochondria function and this HMGCS1 regulatory circuit. Our research bridges a conceptual gap between mitochondria activity, signaling pathways, and metabolic networks conserved from yeast to humans. By placing ubiquitin and sumo as key regulators of HMGCS1 protein, our findings uncover a new link between post-translation modification and mevalonate pathway regulation. At the clinical level, understanding of these mechanisms is likely to lead to new treatment venues for the future treatment of cardiovascular disease and certain types of cancer that are caused by mevalonate pathway hyper-activation. Skills: 1) Western blotting, proteomics 2) Light, fluorescence, and electron microscopy 3) Advance genetic and genomic techniques 4) Assays to measure worm metabolism in vivo 5) Establishing methods to measure mitochondria function in vivo | |||
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Ana Busturia Please log-in to see email and phone. |
Centro de Biología Molecular Severo Ochoa http://web4.cbm.uam.es Spain |
WG1 |
| Speciality:Drosophila development, Epigenetics. Morphogenesis, Apoptosis, Proliferation, microRNAs, Immune response. Skills: Drosophila genetis and molecular genetics, Biochemistry, Molecular Biology. | |||
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Ander Urruticoechea Please log-in to see email and phone. |
Onkologikoa http://www.onkologikoa.org Spain |
WG6 |
| Clinical/ Translational research in cancer | |||
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Andrea Pichler Please log-in to see email and phone. |
Max-Planck Instiute of Immunobiology and Epigenetics http://www3.ie-freiburg.mpg.de Germany |
WG1 |
| E2 enzyme regulation in sumoylation and ubiquitination | |||
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Andreas Bachmair Please log-in to see email and phone. |
University of Vienna http://www.mfpl.ac.at Austria |
WG1 |
| Plant Biology Ubiquitin and related modifiers Retrotransposons | |||
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Andreas Hermann Please log-in to see email and phone. |
Dresden University of Technology http://www.als-dd.de Germany |
WG3 |
| Neurodegenerative Diseases with special focus on Motor Neuron Disease/frontotemporal lobar degeneration and neuroacanthocytosis | |||
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Andriy Sibirny Please log-in to see email and phone. |
Institute of Cell Biology. NAS of Ukraine http://www.cellbiol.lviv.ua Ukraine |
WG3 |
| Speciality: Yeast pexophagy, yeast metabolic engineering Skills: Gene cloning, vector construction, transformation, gene knock out, enzyme assaying, metabolite assaying | |||
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[email protected] Please log-in to see email and phone. |
No website |
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Anita Krisko Please log-in to see email and phone. |
Mediterranean Institute for Life Sciences http://www.medils.org Croatia |
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| Our lab seeks to understand the interplay between protein homeostasis and the cellular metabolic activity, as well as the role it has in decisions regarding cell fate. We focus on elucidation of cellular and molecular mechanisms underlying the proteostasis-metabolism crosstalk within and across cellular compartments. We aim to obtain an integrated picture of the effects that the quality of protein folding environment is able to yield on cellular metabolism, thus contributing to understanding of the implications of this multifaceted network in aging and disease. Understanding this crosstalk may reveal novel insights into basic cellular functioning, but also shed new light on the process of aging, and re-define neurodegenerative diseases. | |||
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Anne Døskeland Please log-in to see email and phone. |
University of Bergen http://www.uib.no Norway |
WG6 |
| Research focus on elucidating the molecular mechanisms of DNA replication in cancer cells and exploiting the results of this research for therapeutic purposes. Active projects focus on understanding the cellular functions and regulation of Cdc7 kinase and on characterizing inhibitors of Cdc7 kinase activity in breast cancer models. More recently we have been involved in understanding how deubiquitinylating enzymes contribute to the stability of replication fork and promote genome stability | |||
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Anne Peyroche Please log-in to see email and phone. |
Institute of Biology and Technologies Saclay (iBiTec-S) http://www-dsv.cea.fr France |
WG2 |
| The team is interested in investigating the assembly, regulations and functions of the proteasome both in yeast and in mammals. We develop specific projects - to identify and characterize proteasome-dedicated assembly chaperones.- to decipher the relationships between the proteasome and the DNA damage response.- to characterize proteasome functions and regulations during quiescence and aging. | |||
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Anne Simonsen Please log-in to see email and phone. |
UiO. Institute of Basic Medical Sciences. Faculty of Medicine http://www.med.uio.no Norway |
WG2 |
| Our work is aimed at understanding the molecular mechanisms involved in regulation and execution of autophagy, the process whereby cytoplasmic components become degraded in the lysosome. Autophagy is an important cell survival mechanism, allowing recycling and reuse of degradation products by the cell to build new macromoleculs or provide energy during situations of cell crisis or stress, but also plays an essential quality control function by selective removal of damage or dysfunctional organelles, as well as protein aggregates and pathogens, thereby being an important tumor-suppressor and neuroprotective pathway. | |||
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Anne-Laure Bulteau Please log-in to see email and phone. |
IPREM http://www.lcabie.com France |
WG6 |
| I am working on mitochondrial proteases especially the Lon protease and its involment in aging and neurodegenerative diseases. Since 2 years I am working on the effects of air pollutants on Lon protease Function. | |||
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Antonio Cuadrado Pastor Please log-in to see email and phone. |
Centro de Investigación Biomédica en Red sobre Enfermedades neurodegenerativas (CIBERNED). Instituto de Investigaciones Biomédicas Alberto Sols UAM-CSIC. Departamento de Bioquímica. Facultad de Medicina. Autonomous University of Madrid. Instituto de Investigación Sanitaria la Paz (IdiPaz) http://ciberned.es Spain |
WG6 |
| Speciality: We study the relevance of transcription factor NRF2 as a new therapeutic target in degenerative diseases. Our main focus is proteinopathies related to Parkinson?s and Alzheimer?s disease. NRF2 controls the expression of proteasome genes and several proteins involved in autophagy (p62 and NDP52).Skills: Molecular and cellular biology, tissue and cell culture, immunohistochemistry and immunofluorescence. Animal handling (mouse and rat), surgery, transgenesis. | |||
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Antonio Velayos-Baeza Please log-in to see email and phone. |
University of Oxford http://www.well.ox.ac.uk United Kingdom |
WG6 |
| Molecular and Cellular Biology aspects of VPS13A and KIAA0319 (and related) proteins. VPS13A gene is altered in the neurological disorder Chorea-Acanthocytosis (ChAc), and KIAA0319 is a Dyslexia Candidate Gene | |||
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Ari Sadanandom Please log-in to see email and phone. |
Durham University http://www.dur.ac.uk United Kingdom |
WG3 |
| The role of protein modification in plant stress signaling. | |||
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Arkaitz Carracedo Perez Please log-in to see email and phone. |
CIC bioGUNE http://personal.cicbiogune.es Spain |
WG6 |
| Cancer metabolism and signaling, prostate cancer, breast cancer, preclinical trials, clinical studies, translational research | |||
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Ashraf Brik Please log-in to see email and phone. |
Technion-Israel Institute of Technology http://www.ahlannet.com Israel |
WG1 |
| Speciality:Chemical Biology of the Ubiquitin Signal. Skills: Chemical and semisynthesis of ubiquitinated peptides and proteins | |||
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Aude Echalier Please log-in to see email and phone. |
University of Leicester. Departments of Biochemistry and of Cancer Studies and Molecular Medicine http://www2.le.ac.uk United Kingdom |
WG2 |
| isopeptidase activity of the Cop9 signalosome, a multiprotein complex that directly controls the activity of the most preponderant E3 ubiquitin ligase family, the cullin RING ubiquitin ligases (CRLs). The main focus of our work is the catalytic subunit of the Cop9 signalosome, CSN5 (also known as Jab1) that is a Zinc-isopeptidase in the context of the complex. CSN5 is also found independently of the Cop9 signalosome complex and could have distinct functions. An integrated molecular approach is used to characterize the catalytic activity of the Cop9 signalosome. To gain further insights in the functions of CSN5, we are studying its interactions with cellular protagonists outside of the Cop9 signalosome complex, in particular in relation with the control of the cell division cycle | |||
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Augustin Catalin Mot Please log-in to see email and phone. |
Babes-Bolyai University, Faculty of Chemistry and Chemical Engineering http://www.chem.ubbcluj.ro Romania |
WG1 |
| Plant enzymology, chemometrics applied in plant metabolomics. | |||
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Ben Voysey Please log-in to see email and phone. |
VIVA Bioscience Ltd. http://www.vivabioscience.com United Kingdom |
WG2 |
| Development of specialist tools, assays and technologies to address key challenges in the autophagy, proteasome, ubiquitin and apoptosis fields, including drug discovery, and biomarker detection and analysis in cancer and neurodegenerative disease. In addition VIVA has a growing interest in lipid detection and analysis. | |||
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Benedikt M. Kessler Please log-in to see email and phone. |
No website United Kingdom |
WG1 |
| Speciality: In our group, we are focused on using proteomics, mass spectrometry and biochemical approaches to understand disease processes. A particular focus is given to discover novel links between the ubiquitin system and human pathology. Skills: Ubiquitin biochemistry; Mass spectrometry; Protein interaction; Drug discovery;Cancer biology & Immunology | |||