Action Members are any researcher who participates actively in PROTEOSTASIS. All Members belong to one or more Working Group. Members can include researchers from COST Countries, Near Neighbour and International Partner Countries.

Adrian Danek

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Neurologische Klinik. Ludwig-Maximilians-Universität
http://www.e-rare.eu
Germany
WG6
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Diagnosis and treatment of neurodegenerative brain disease
Adrienne Gorman

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National University of Ireland. Galway
http://www.nuigalway.ie
Ireland
WG4
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Speciality: Previous and ongoing research in my group is in the area of stress responses, including the unfolded protein response and heat shock responses. Both of these play a role in promoting cell survival in the face of disruption to cellular proteostasis. Other ongoing research is in the area of cell death, particularly apoptosis, where there is activation of proteolytic pathways (mainly the caspase cascade) that mediate degradation of cellular proteins. Recent published work from my group shows a novel mechanism implicating lysosomal degradation of active caspase proteases that is induced by a pro-survival growth factor. Skills: Biochemistry, cell biology, molecular biology
Agnieszka Sirko

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Institute of Biochemistry and Biophysiscs
http://www.ibb.waw.pl
Poland
WG2
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Selective autophagy in plants and its role in plant response to environmental stresses (with focus on nutrient deficiency). Molecular mechanisms responsible for signaling and regulation of plant response to nutrient deficiency stress and other abiotic stresses (with focus on the role of posttranslational processes). Regulation of plant response to sulfur deficiency. DNA vaccines, vaccines against influenza virus (with main focus on birds)
Alberto Ferrús

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Instituto Cajal. CSIC
http://www.ferrus-flysynapse.es
Spain
WG3
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Genetic and functional studies of Drosophila synapses under normal and pathological conditions. In particular, under the genetically driven expression of human beta amyloid peptides.
Alfred C.O. Vertegaal

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Molecular Cell Biology. Leiden University Medical Center
http://www.lumc.nl
Netherlands
WG1
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Our group is interested in protein SUMOylation, a post-translational modification that predominantly regulates nuclear processes including transcription and the DNA damage response. We use protein purification and mass spectrometry to obtain system-wide insight in SUMO- and also ubiquitin signaling in response to different stimuli. We have developed different purification procedures to obtain system-wide insight in protein SUMOylation and ubiquitination. Novel site-specific methods are being developed. Using quantitative proteomics, we are studying SUMOylation dynamics upon DNA damage. Selected novel SUMO targets are studied at the functional and mechanistic level.
Alicia Alonso

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University of the Basque Country UPV/EHU. CSIC
http://www.unidaddebiofisica.org
Spain
WG2
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Membrane biophysics. Model membranes. Protein-lipid interactions. Autophagy.
Amir Oryan

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Technion
http://www.technioncancer.co.il
Israel
WG5
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Role of SUMO and ubiquitin signaling in adult tissue homeostasis focusing on adult gut, innate immunity. Impact of Ub/UbL on development and cancer. Specific focus on the Role of SUMO-Targeted ubiquitin ligases in development and cancer.
Amir Sapir

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No website
Israel
WG2
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Speciality: I have established the Nematode C. elegans as a genetic and proteomic platform to study the regulation of the mevalonate pathway that is critical for cholesterol biosynthesis as well as for the synthesis of metabolites required for small GTPase protein activation and cellular respiration. We discovered a previously unknown regulatory circuit that controls the sumoylation and ubiquitination levels of the first enzyme in the pathway, HMGCS1. We further characterized this circuit and found how it is regulated temporally by an age-dependent cytosol-to-mitochondria sorting of specific circuit components. Recently, we have found a strong connection between mitochondria function and this HMGCS1 regulatory circuit. Our research bridges a conceptual gap between mitochondria activity, signaling pathways, and metabolic networks conserved from yeast to humans. By placing ubiquitin and sumo as key regulators of HMGCS1 protein, our findings uncover a new link between post-translation modification and mevalonate pathway regulation. At the clinical level, understanding of these mechanisms is likely to lead to new treatment venues for the future treatment of cardiovascular disease and certain types of cancer that are caused by mevalonate pathway hyper-activation. Skills: 1) Western blotting, proteomics 2) Light, fluorescence, and electron microscopy 3) Advance genetic and genomic techniques 4) Assays to measure worm metabolism in vivo 5) Establishing methods to measure mitochondria function in vivo
Ana Busturia

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Centro de Biología Molecular Severo Ochoa
http://web4.cbm.uam.es
Spain
WG1
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Speciality:Drosophila development, Epigenetics. Morphogenesis, Apoptosis, Proliferation, microRNAs, Immune response. Skills: Drosophila genetis and molecular genetics, Biochemistry, Molecular Biology.
Ander Urruticoechea

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Onkologikoa
http://www.onkologikoa.org
Spain
WG6
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Clinical/ Translational research in cancer
Andrea Pichler

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Max-Planck Instiute of Immunobiology and Epigenetics
http://www3.ie-freiburg.mpg.de
Germany
WG1
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E2 enzyme regulation in sumoylation and ubiquitination
Andreas Bachmair

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University of Vienna
http://www.mfpl.ac.at
Austria
WG1
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Plant Biology Ubiquitin and related modifiers Retrotransposons
Andreas Hermann

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Dresden University of Technology
http://www.als-dd.de
Germany
WG3
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Neurodegenerative Diseases with special focus on Motor Neuron Disease/frontotemporal lobar degeneration and neuroacanthocytosis
Andriy Sibirny

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Institute of Cell Biology. NAS of Ukraine
http://www.cellbiol.lviv.ua
Ukraine
WG3
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Speciality: Yeast pexophagy, yeast metabolic engineering Skills: Gene cloning, vector construction, transformation, gene knock out, enzyme assaying, metabolite assaying
ane.olazabal@ehu.es

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No website

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Anne Døskeland

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University of Bergen
http://www.uib.no
Norway
WG6
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Research focus on elucidating the molecular mechanisms of DNA replication in cancer cells and exploiting the results of this research for therapeutic purposes. Active projects focus on understanding the cellular functions and regulation of Cdc7 kinase and on characterizing inhibitors of Cdc7 kinase activity in breast cancer models. More recently we have been involved in understanding how deubiquitinylating enzymes contribute to the stability of replication fork and promote genome stability
Anne Peyroche

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Institute of Biology and Technologies Saclay (iBiTec-S)
http://www-dsv.cea.fr
France
WG2
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The team is interested in investigating the assembly, regulations and functions of the proteasome both in yeast and in mammals. We develop specific projects - to identify and characterize proteasome-dedicated assembly chaperones.- to decipher the relationships between the proteasome and the DNA damage response.- to characterize proteasome functions and regulations during quiescence and aging.
Anne Simonsen

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UiO. Institute of Basic Medical Sciences. Faculty of Medicine
http://www.med.uio.no
Norway
WG2
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Our work is aimed at understanding the molecular mechanisms involved in regulation and execution of autophagy, the process whereby cytoplasmic components become degraded in the lysosome. Autophagy is an important cell survival mechanism, allowing recycling and reuse of degradation products by the cell to build new macromoleculs or provide energy during situations of cell crisis or stress, but also plays an essential quality control function by selective removal of damage or dysfunctional organelles, as well as protein aggregates and pathogens, thereby being an important tumor-suppressor and neuroprotective pathway.
Anne-Laure Bulteau

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IPREM
http://www.lcabie.com
France
WG6
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I am working on mitochondrial proteases especially the Lon protease and its involment in aging and neurodegenerative diseases. Since 2 years I am working on the effects of air pollutants on Lon protease Function.
Antonio Cuadrado Pastor

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Centro de Investigación Biomédica en Red sobre Enfermedades neurodegenerativas (CIBERNED). Instituto de Investigaciones Biomédicas Alberto Sols UAM-CSIC. Departamento de Bioquímica. Facultad de Medicina. Autonomous University of Madrid. Instituto de Investigación Sanitaria la Paz (IdiPaz)
http://ciberned.es
Spain
WG6
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Speciality: We study the relevance of transcription factor NRF2 as a new therapeutic target in degenerative diseases. Our main focus is proteinopathies related to Parkinson?s and Alzheimer?s disease. NRF2 controls the expression of proteasome genes and several proteins involved in autophagy (p62 and NDP52).Skills: Molecular and cellular biology, tissue and cell culture, immunohistochemistry and immunofluorescence. Animal handling (mouse and rat), surgery, transgenesis.
Antonio Velayos-Baeza

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University of Oxford
http://www.well.ox.ac.uk
United Kingdom
WG6
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Molecular and Cellular Biology aspects of VPS13A and KIAA0319 (and related) proteins. VPS13A gene is altered in the neurological disorder Chorea-Acanthocytosis (ChAc), and KIAA0319 is a Dyslexia Candidate Gene
Ari Sadanandom

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Durham University
http://www.dur.ac.uk
United Kingdom
WG3
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The role of protein modification in plant stress signaling.
Arkaitz Carracedo Perez

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CIC bioGUNE
http://personal.cicbiogune.es
Spain
WG6
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Cancer metabolism and signaling, prostate cancer, breast cancer, preclinical trials, clinical studies, translational research
Ashraf Brik

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Technion-Israel Institute of Technology
http://www.ahlannet.com
Israel
WG1
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Speciality:Chemical Biology of the Ubiquitin Signal. Skills: Chemical and semisynthesis of ubiquitinated peptides and proteins
Aude Echalier

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University of Leicester. Departments of Biochemistry and of Cancer Studies and Molecular Medicine
http://www2.le.ac.uk
United Kingdom
WG2
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isopeptidase activity of the Cop9 signalosome, a multiprotein complex that directly controls the activity of the most preponderant E3 ubiquitin ligase family, the cullin RING ubiquitin ligases (CRLs). The main focus of our work is the catalytic subunit of the Cop9 signalosome, CSN5 (also known as Jab1) that is a Zinc-isopeptidase in the context of the complex. CSN5 is also found independently of the Cop9 signalosome complex and could have distinct functions. An integrated molecular approach is used to characterize the catalytic activity of the Cop9 signalosome. To gain further insights in the functions of CSN5, we are studying its interactions with cellular protagonists outside of the Cop9 signalosome complex, in particular in relation with the control of the cell division cycle
Ben Voysey

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VIVA Bioscience Ltd.
http://www.vivabioscience.com
United Kingdom
WG2
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Development of specialist tools, assays and technologies to address key challenges in the autophagy, proteasome, ubiquitin and apoptosis fields, including drug discovery, and biomarker detection and analysis in cancer and neurodegenerative disease. In addition VIVA has a growing interest in lipid detection and analysis.
Benedikt M. Kessler

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No website
United Kingdom
WG1
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Speciality: In our group, we are focused on using proteomics, mass spectrometry and biochemical approaches to understand disease processes. A particular focus is given to discover novel links between the ubiquitin system and human pathology. Skills: Ubiquitin biochemistry; Mass spectrometry; Protein interaction; Drug discovery;Cancer biology & Immunology
Bernat Crosas Navarro

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Instituto de Biología Molecular de Barcelona
http://www.ibmb.csic.es
Spain
WG2
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To examine novel levels of regulation of the proteasome pathway focusing on the mechanisms that control proteasome function and its interaction with protein substrates
Bertrand Friguet

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University Pierre and Marie Curie (UPMC)
http://www.ibps.upmc.fr
France
WG6
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Our goals are to elucidate the role of protein oxidation as well as oxidized protein degradation and repair during cellular ageing in vitro and ex vivo and in situations of oxidative stress leading to accelerated ageing. We are also currently investigating the relationship between oxidative stress, protein homeostasis and circadian rhythmicity in relevant cellular models.
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