The 2018 FASEB Summer Research Conference on Ubiquitin and Cellular Regulation will be held at Snowmass, Colorado, June 17 to 22, 2018. The FASEB-sponsored conference has been held biannually since 1989 and since then it has become the pre-eminent conference for the field of protein ubiquitination. The conference will bring together approximately 150 investigators (junior and senior scientists, postdoctoral fellows, graduate students, and people from industry and government) and will focus on the importance of protein ubiquitination, protein turnover, and modification by ubiquitin-like proteins (UBLs) in many diseases, including cancer, neurologic and developmental diseases, and viral and microbial infectious diseases. We anticipate that important new developments will be presented on the identification of strategies and pharmacologic agents that modulate the activities of ubiquitin/ UBLs pathway enzymes and the proteasome. The FASEB SRC format provides a unique environment that encourages informal and open discussions among the participants and this in turn fosters initiation of collaborative efforts and stimulates future research directions to broaden the understanding of the roles of ubiquitin, the proteasome, and UBLs in health and disease.