On the 12th December 2017, PROTEOSTASIS organized, with the support of Bio-Techne, a  Webinar titled “20 years and getting stronger – the Ins and Outs of SUMOylation” and delivered by Professor Frauke Melchior. Professor Frauke Melchior provided an overview of fundamental mechanisms and highlighted recent developments in the analysis and physiology of sumoylation. Hundreds of proteins involved in processes such as chromatin organization, transcription, DNA repair, macromolecular assembly and protein homeostasis, trafficking and signal transduction are subject to reversible sumoylation.